A New Approach for Treatment and Prevention of Recurrent Oral Lichen Planus: A Technical Report

Introduction: Oral lichen planus (OLP) is an autoimmune disease with uncertain etiopathogenecity and no definitive treatment. Considering the recurrent nature of OLP, finding an adjunctive treatment to minimize the risk of chronicity and recurrence of OLP and to decrease the adverse effects of corticosteroids can be promising. This study aimed to assess the efficacy of a mixture of hyaluronic acid and triamcinolone in the treatment of OLP. Case Presentation: This study involved five OLP patients. In each patient, the mixture of hyaluronic acid/triamcinolone was injected intralesionally into the case lesion, while triamcinolone alone was injected into the control lesion. The patients were followed-up at 14 and 28 days post-intervention and then monthly for 9 months. Recurrences were observed in three control lesions, while the patients did not show any aggravation or recurrence in the case lesions. Conclusion: It appears that triamcinolone/hyaluronic acid mixture is potentially beneficial in the treatment of OLP.